A researcher for Brazil’s state-run Fiocruz Institute takes an oral swab sample from a bat captured in the Atlantic Forest, at Pedra Branca state park, near Rio de Janeiro, Tuesday, Nov. 17, 2020. Teams of researchers around the globe are racing to study the places and species from which the next pandemic may emerge. It’s no coincidence that many scientists are focusing attention on the world’s only flying mammals — bats. (AP Photo/Silvia Izquierdo)

A researcher for Brazil’s state-run Fiocruz Institute takes an oral swab sample from a bat captured in the Atlantic Forest, at Pedra Branca state park, near Rio de Janeiro, Tuesday, Nov. 17, 2020. Teams of researchers around the globe are racing to study the places and species from which the next pandemic may emerge. It’s no coincidence that many scientists are focusing attention on the world’s only flying mammals — bats. (AP Photo/Silvia Izquierdo)

VIDEO: Scientists focus on bats for clues to prevent next pandemic

It’s no coincidence that many scientists are focusing attention on the world’s only flying mammals — bats

Night began to fall in Rio de Janeiro’s Pedra Branca state park as four Brazilian scientists switched on their flashlights to traipse along a narrow trail of mud through dense rainforest. The researchers were on a mission: capture bats and help prevent the next global pandemic.

A few meters ahead, nearly invisible in the darkness, a bat made high-pitched squeaks as it strained its wings against the thin nylon net that had ensnared it. One of the researchers removed the bat, which used its pointed teeth to bite her gloved fingers.

The November nighttime outing was part of a project at Brazil’s state-run Fiocruz Institute to collect and study viruses present in wild animals — including bats, which many scientists believe were linked to the outbreak of COVID-19.

The goal now is to identify other viruses that may be highly contagious and lethal in humans, and to use that information to devise plans to stop them from ever infecting people — to forestall the next potential global disease outbreak before it gets started.

In a highly connected world, an outbreak in one place endangers the entire globe, just as the coronavirus did. And the Brazilian team is just one among many worldwide racing to minimize the risk of a second pandemic this century.

To some, it might seem too soon to contemplate the next global outbreak, with the world still grappling with the devastating fallout of the ongoing one. But scientists say it’s highly like that, without savvy intervention, another novel virus will jump from animal to human host and find the conditions to spread like wildfire.

As this pandemic has shown, modern transport can disperse the pathogen to all corners of the globe in a matter of hours and spread easily in densely populated cities.

It’s not a question of if, but of when, according to Dr. Gagandeep Kang, an infectious diseases expert at Christian Medical College at Vellore in southern India.

She pointed to previous research that found India was among the most likely places in the world for such a “spillover” event to occur, due to population density and increasing human and livestock incursion into its dense tropical forests teeming with wildlife.

It’s no coincidence that many scientists are focusing attention on the world’s only flying mammals — bats.

Bats are thought to be the original or intermediary hosts for multiple viruses that have spawned recent epidemics, including COVID-19, SARS, MERS, Ebola, Nipah virus, Hendra virus and Marburg virus. A 2019 study found that of viruses originating from the five most common mammalian sources — primates, rodents, carnivores, ungulates and bats — those from bats are the most virulent in humans.

Bats are a diverse group, with more than 1,400 species flitting across every continent except Antarctica. But what many have in common are adaptations that allow them to carry viruses that are deadly in humans and livestock while exhibiting minimal symptoms themselves — meaning they are able travel and shed those viruses, instead of being quickly hobbled.

“The secret is that bats have unusual immune systems, and that’s related to their ability to fly,” said Raina Plowright, an epidemiologist who studies bats at Montana State University.

To get off the ground and sustain flight requires an incredible amount of energy, with bats’ metabolic rate increasing sixteen-fold, Plowright said. “You’d expect them to get cell damage from all that metabolic exertion,” she said.

But that doesn’t happen. Instead, bats are remarkably resilient, with many species living more than 30 years — highly unusual for such small mammals.

Plowright and other bat scientists believe evolutionary tweaks that help bats recover from the stress of flying also give them extra protection against pathogens.

“Bats seem to have evolved a collateral benefit of flight — resistance to deal with some of the nastiest viruses known to science,” said Arinjay Banerjee, a virologist at McMaster University in Canada.

While scientists are still untangling the mystery, two leading theories are that bats may have evolved what Banerjee called “an efficient DNA repair mechanism” or that their bodies may tightly regulate inflammation triggers and not overreact to viral infections.

Probing the secrets of bat immune systems may help scientists understand more about when bats do shed viruses, as well as providing hints for possible future medical treatment strategies, he said.

Bats and other animals that carry pathogens don’t innately pose a risk to humans — unless conditions are right for a spillover event. “The virus has to come out of the host for us to get infected,” said Cara Brook, a disease ecologist at the University of California, Berkeley.

The bad news: Increasing destruction and fragmentation of habitats worldwide — especially biodiverse areas like tropical forests — means “we are seeing higher rates of contact between wildlife and humans, creating more opportunities for spillover,” she said.

That’s why the Brazilian researchers chose Pedra Branca park. As one of the world’s largest forests within an urban area, it offers a constant interaction of wild animals with the thousands of humans and domestic animals in surrounding communities. The scientists are studying not just bats, but also small primates, wild cats and domestic cats in homes with confirmed COVID-19 cases.

Scientists and governments would stand a better chance at containing future outbreaks if they had faster notice of when and where they begin, said Ian Mackay, a virologist at Australia’s University of Queensland.

“Ongoing, constant, nonstop surveillance,” along the lines of the flu labs set up by the World Health Organization across the globe, could help researchers be better prepared, he said. He also suggested that labs for virus discovery could regularly sample waste water or materials from hospitals.

In India, a National Mission on Biodiversity and Human Well-Being has been pending since 2018 and will likely be launched next year. Abi Tamim Vanak, a conservation scientist at Ashok Trust for Research in Ecology and Environment in Bengaluru, said that a core part of the plan is to set up 25 sentinel surveillance sites across the country in both rural and urban areas.

“They will be the first line of defence,” he said.

A varied patchwork of virus surveillance programs exists in several countries, but funding tends to wax and wane with the political climate and sense of urgency.

Among the most ambitious endeavours is the Global Virome Project, which aims to discover 500,000 new viruses over 10 years.

The U.S. Agency for International Development recently announced the launch of the $100 million STOP Spillover project, an effort led by scientists at Tufts University and including global partners to study zoonotic diseases in Africa and Asia.

One approach that won’t help, scientists say, is treating bats as the enemy – vilifying them, throwing stones or trying to burn them out of caves.

This spring, villagers in the Indian state of Rajasthan identified bat colonies in abandoned forts and palaces and killed hundreds with bats and sticks. They also sealed some crevices where the bats lived, effectively trapping them. In the Indian state of Karnataka, villagers cut down old trees where bats tend to roost.

Scientists say those those tactics are likely to backfire.

An investigation by the U.S. Centers for Disease Control and Prevention and Ugandan health authorities found that, after a mining operation attempted to exterminate bats from a cave in Uganda, the remaining bats exhibited higher infection levels of Marburg virus. This led to Uganda’s most severe outbreak of Marburg hemorrhagic fever, caused by the virus, in 2012.

“Stress is a huge factor in upsetting the natural balance that bats have with their viruses — the more you stress bats, the more they shed viruses,” said Vikram Misra, a virologist at the University of Saskatchewan in Canada.

Although orders issued by Indian forest officials reiterating the complete ban on killing of wildlife and information campaigns to dispel myths were largely successful, convincing people not to attack bats means dispelling long-running cultural assumptions.

“People have a lot of misconceptions about bats. They’re nocturnal and look a little weird flying, and there’s a lot of literature and culture built around bats being scary,” said Hannah Kim Frank, a biologist at Tulane University. “But bats aren’t aggressive — and attacking bats doesn’t help control diseases.”

Bats also play vital roles in ecosystems: They consume insects like mosquitos, pollinate plants like agave, and disperse seeds.

“We actually need bats in the wild to consume insects that otherwise destroy cotton, corn and pecan harvests,” said Kristen Lear, an ecologist at Bat Conservational International.

A better approach to minimize disease risk, Frank said, is simply to minimize contact between wild bats and people and livestock.

She suggested that research on when bats migrate, and when new pups are born, could inform decisions about when people should avoid certain areas or keep their livestock penned up.

In North America, some scientists advocate restricting public access to caves where bats roost.

“Cave gating — bat-friendly gates, built with iron crossbars — can keep humans out and allow bats to move freely,” said Kate Langwig, an infectious disease ecologist at Virginia Tech. “If we leave the bats alone, and don’t try to hurt or exterminate them, they are going to be healthier.”

Perhaps the most significant factor bringing bats into more frequent contact with people and domestic animals is the destruction of habitat, which forces bats to seek out new foraging and roosting grounds.

In Australia, widespread destruction of winter flowering eucalyptus trees that provide nectar for fruit bats — known locally as “flying foxes” — prompted the bats to move into areas closer to human settlements looking for alternate meals, including to a suburb of Brisbane called Hendra.

There, the bats transmitted a virus to horses, which in turn infected people. First identified in 1994 and named Hendra virus, it is highly lethal, killing 60% of people and 75% of horses infected.

A similar chain of events took place in Bangladesh, when habitat destruction drove fruit bats into cities, where they spread Nipah virus, which causes severe encephalitis in humans, by licking date palm sap from collection barrels.

To potentially reverse the movement of bats, Montana State University’s Plowright and colleagues based in Australia are studying restoring the bats’ original habitat.

“Every city in Australia is full of fruit bats that lost their winter habitats,” she said. “The idea is to plant new forests and make sure they are away from places with domestic animals and people.”

Whether the goal is to curb the spread of known zoonotic diseases or to reduce the risk of new ones emerging as pandemics, the strategy is the same: Reduce contact between humans and wild animals.

“In the history of COVID-19, bats have been more victim than victimizer,” said Ricardo Moratelli, co-ordinator of the Fiocruz project in Brazil. “Bats host a large number of parasites, and they deal with these parasites well. The problem is when human beings enter into contact with them.”

Christina Larson, Aniruddha Ghosal And Marcelo Silva De Sousa, The Associated Press

Coronavirus

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Tim Schewe
Drivesmart column: Do you know someone who should not be driving?

We are currently living about 10 years longer than our ability to drive safely.

Chris Wilkinson
Chris Wilkinson column: Time to slow down to speed up

In a society where we learn (are forced?) to multitask like crazy

A COVID-19 exposure has been reported at Shawnigan Lake School. (Citizen file photo)
UPDATED: Island Health reports COVID-19 exposure at Shawnigan Lake School

Shawnigan Lake School has been added to the list of schools in… Continue reading

Peas are great to grow in the garden, but a trellis for them in an A frame shape will offer more portability and wind resistance. (Citizen file)
Mary Lowther column: Making a foldable pea trellis on winter agenda

My previous methods required starting anew every spring

Sarah Simpson
Sarah Simpson Column: Books open up a world of discovery

We try to eat dinner as a family every night. It happens… Continue reading

Terrance Josephson of the Princeton Posse, at left, and Tyson Conroy of the Summerland Steam clash during a Junior B hockey game at the Summerland Arena in the early spring of 2020. (John Arendt - Summerland Review)
QUIZ: How much do you know about hockey?

Test your knowledge of Canada’s national winter sport

Dr. Jerome Leis and Dr. Lynfa Stroud are pictured at Sunnybrook Hospital in Toronto on Thursday, January 21, 2021.THE CANADIAN PRESS/Frank Gunn
‘It wasn’t called COVID at the time:’ One year since Canada’s first COVID-19 case

The 56-year-old man was admitted to Toronto’s Sunnybrook Health Sciences Centre

An Uber driver’s vehicle is seen after the company launched service, in Vancouver, Friday, Jan. 24, 2020. Several taxi companies have lost a court bid to run Uber and Lyft off the road in British Columbia. THE CANADIAN PRESS/Darryl Dyck
Taxi companies lose court bid to quash Uber, Lyft approvals in British Columbia

Uber said in a statement that the ruling of the justice is clear and speaks for itself

Nanaimo Regional General Hospital. (News Bulletin file photo)
COVID-19 outbreak declared at Nanaimo hospital

Two staff members and one patient have tested positive, all on the same floor

A long-term care worker receives the Pfizer vaccine at a clinic in Nanaimo earlier this month. (Island Health photo)
All Island seniors in long-term care will be vaccinated by the end of this weekend

Immunization of high-risk population will continue over the next two months

A 75-year-old aircraft has been languishing in a parking lot on the campus of the University of the Fraser Valley, but will soon be moved to the B.C. Aviation Museum. (Paul Henderson/ Chilliwack Progress)
Vintage military aircraft moving from Chilliwack to new home at B.C. Aviation Museum

The challenging move to Vancouver Island will be documented by Discovery Channel film crews

A video posted to social media by Chilliwack resident Rob Iezzi shows a teenager getting kicked in the face after being approached by three suspects on Friday, Jan. 22, 2021. (YouTube/Rob i)
VIDEO: Security cameras capture ‘just one more assault’ near B.C. high school

Third high-school related assault captured by Chilliwack resident’s cameras since beginning of 2021

FILE - In this Feb. 14, 2017, file photo, Oklahoma State Rep. Justin Humphrey prepares to speak at the State Capitol in Oklahoma City. A mythical, ape-like creature that has captured the imagination of adventurers for decades has now become the target of Rep. Justin Humphrey. Humphrey, a Republican House member has introduced a bill that would create a Bigfoot hunting season, He says issuing a state hunting license and tag could help boost tourism. (Steve Gooch/The Oklahoman via AP, File)
Oklahoma lawmaker proposes ‘Bigfoot’ hunting season

A Republican House member has introduced a bill that would create a Bigfoot hunting season

Economic Development and Official Languages Minister Melanie Joly responds to a question in the House of Commons Monday November 23, 2020 in Ottawa. THE CANADIAN PRESS/Adrian Wyld
Federal minister touts need for new B.C. economic development agency

Last December’s federal economic update promised a stimulus package of about $100 billion this year

Most Read