Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Infants should be tested for autism if older siblings are diagnosed, Canadian study suggests

Blood test for infants with sibling who’s been diagnosed would get information to families earlier

Canadian researchers have led a study suggesting infants be tested for autism spectrum disorder before symptoms appear if an older sibling has already been diagnosed with the neurobiological condition.

The odds of a younger sibling having autism are up to 20 per cent, but most children miss out on early intervention for challenges in behaviour and communication because they’re often not diagnosed until age four, previous studies have shown.

Research by Dr. Stephen Scherer, senior scientist and director of the Centre for Applied Genomics at the Hospital for Sick Children in Toronto, and Dr. Lonnie Zwaigenbaum, a professor of pediatrics at the University of Alberta, found a standard blood test analyzing the DNA of infants with a sibling who’s been diagnosed with autism would provide earlier information for families.

The findings were published Thursday in the journal Nature Communications.

They involve 288 infant siblings from Canada and the United States showing that by age three, 157 of the children were either diagnosed with autism spectrum disorder or developing atypically. Of the 157 children, seven per cent were carrying a gene that put them at a very high risk of developing autism.

RELATED: New study suggests autism overdiagnosed, Canadian expert says

Of the seven per cent of kids, 50 per cent were diagnosed with autism by age three and an additional 35 per cent had other developmental challenges.

Scherer said families of autistic children are often concerned about whether a sibling could also be at risk.

“It’s the number one question families have and no one’s ever wrapped any statistics around that and that’s what we present for the first time, with this paper,” he said.

Further genetic testing looking at the entire genome, beyond a blood test called microarray analysis, is being conducted with all the families in the study in hopes it will provide more information about the risk of autism, Scherer said.

The participants were part of the Baby Siblings Research Consortium, which includes independent research groups in Canada, the United States and Europe, though this study included 10 sites in North America, four of them in Canada, Zwaigenbaum said of the testing that is part of an ongoing decade-long research project looking at behavioural predictors of autism.

“Based on the findings of the study, we’re suggesting that the test be focused on younger siblings,” he said. “It could be informative at a time where we’re not likely to see any behavioural signs. So it provides an option for presymptomatic testing to identify infants at highest risk.”

READ MORE: Autism support dog refused bus access for being a ‘pet’

Families who are informed about a younger child’s risk of autism could initiate strategies to help them develop early communication skills before assessment of behaviour by a specialist and intervention by a therapist as part of a cost-effective approach to care, Zwaigenbaum said.

“I think we may be moving to an exciting new time where both biomarkers and developmental surveillance can provide complementary information to help us identify infants at risk.”

Camille Bains, The Canadian Press

Like us on Facebook and follow us on Twitter

Just Posted

Robert’s column
Robert Barron Column: Poachers in forest reserve should be treated harshly

‘Poachers need to be rounded up and prosecuted as soon as possible’

Can you dig it? Crofton In Bloom volunteers certainly can. From left: Trayci Lepp, Tony Lamley, Bonnie Lamley, Mary Patient and Jane Grueber. (Photo by Don Bodger)
Community pride grows from volunteer group’s beautification efforts

All ages contribute to Crofton In Bloom’s objectives

An object in motion stays in motion. An object at rest stays at rest. (Sarah Simpson/Citizen)
Sarah Simpson Column: This mother is grinning and bearing it

News broke the other day that, after months in hibernation, Grouse Mountain’s… Continue reading

An online cooking lesson with Ian Blom, the Red Seal Chef from the Ainslie Restaurant, is one of the items on auction in a fundraiser for the Duncan Curling Club and other causes. (Submitted photo)
Online action being held to assist Duncan Curling Club and other causes

Auction, run by the Duncan Rotary Club, closes May 22

Daily confirmed COVID-19 cases reported to B.C. public health, seven-day rolling average in white, to May 12, 2021. (B.C. Centre for Disease Control)
B.C. preparing ‘Restart 2.0’ from COVID-19 as June approaches

Daily infections fall below 500 Friday, down to 387 in hospital

On Friday, May 14 at Meadow Gardens Golf Club in Pitt Meadows, Michael Caan joined a very elite club of golfers who have shot under 60 (Instagram)
Crowds at English Bay were blasted with a large beam of light from an RCMP Air-1 helicopter on Friday, May 14. THE CANADIAN PRESS/Marc Grandmaison
Police enlist RCMP helicopter to disperse thousands crowded on Vancouver beach

On Friday night, police were witness to ‘several thousand people staying well into the evening’

Sinikka Gay Elliott was reported missing on Salt Spring Island on Wednesday, May 12. (Courtesty Salt Spring RCMP)
Body of UBC professor found on Salt Spring Island, no foul play suspected

Sinikka Elliott taught sociology at the university

The first Black judge named to the BC Supreme Court, Selwyn Romilly, was handcuffed at 9:15 a.m. May 14 while walking along the seawall. (YouTube/Screen grab)
Police apologize after wrongly arresting B.C.’s first Black Supreme Court Justice

At 81 years old, the retired judge was handcuffed in public while out for a walk Friday morning

Queen Elizabeth II and Clive Holland, deputy commonwealth president of the Royal Life Saving Society, top left, virtually present Dr. Steve Beerman, top right, with the King Edward VII Cup for his drowning-prevention work. Tanner Gorille and Sarah Downs were honoured with Russell Medals for their life-saving resuscitation. (Buckingham Palace photo)
Queen presents Vancouver Island doctor with award for global drowning prevention

Dr. Steve Beerman receives Royal Life Saving Society’s King Edward VII Cup at virtual ceremony

Former UFV Cascades wrestling coach Arjan Singh Bhullar is now the ONE heavyweight champion after defeating Brandon Vera via TKO in round two on Saturday in Singapore. (ONE Championship)
Former UFV wrestling coach wins MMA championship

Arjan Singh Bhullar captures ONE heavyweight title, first Indian origin fighter to achieve honour

Astra Zeneca vaccine waits for injection in a Feb. 3, 2021 file photo. A Langley man has become the second B.C. resident to suffer a blood clot following an injection. (AP Photo/Frank Augstein)
B.C. man required emergency surgery after AstraZeneca vaccination

Shaun Mulldoon suffered ‘massive blood clot’ after jab

Chilliwack’s Kile Brown, performing as drag queen Hailey Adler, dances and lip syncs in front of hundreds of people during the inaugural Chilliwack Pride Barbecue at the Neighbourhood Learning Centre on Aug. 24, 2019. Monday, May 17 is International Day Against Homophobia, Transphobia and Biphobia. (Jenna Hauck/ Chilliwack Progress file)
Unofficial holidays: Here’s what people are celebrating for the week of May 16 to 22

International Day Against Homophobia, Talk Like Yoda Day, Sea Monkey Day all coming up this week

Most Read